It's quite a tricky question. What if the last word is "antidisestablishmentarianism"? Some publishers specify a minimum number of characters on the last line, excluding punctuation. Others specify a minimum length—such as clearing the paragraph indent. There's been some discussion of this in the CSS Working Group recently. One proposal was for a "last-line-length" property which would take a percentage value.
I just thought that it is extremely very rare case that word exists in any book, and it is also true that there is no rule if it is there that this will be a last word of the paragraph.
By looking at the standard/regular words that they written for last word to a paragraph, I got feeling of whether it is possible or not.
It's also a problem for single characters. In French, exclamation points (for example) are supposed to have a space before them. Which means they can end up on their own on the last line of a paragraph. And it makes people sad...